Osteoporosis is a disease in which the density and quality of bone are reduced, leading to weakness of the skeleton and increased risk of fracture, particularly of the spine, wrist, hip, pelvis and upper arm. In many affected people, bone loss is gradual and without symptoms or warning signs until the disease is advanced. Osteoporosis is a global problem which is increasing in significance as the population of the world both grows and ages. For these reasons, osteoporosis is often referred to as the "silent epidemic".
CLASSIFICATIONS
Primary Osteoporosis - caused by estrogen deficiency. It is much more common in women than men. Type I - is called "postmenopausal osteoporosis," typically occurring within 15 to 20 years of menopause. Type II - is caused by low calcium. Chronic calcium deficiency leads to decreased bone formation and fragile bones. Type ll osteoporosis usually occurs in people over 70 and is, therefore, called "senile osteoporosis."
Secondary Osteoporosis - is age-related osteopororosis generally seen in the elderly of both sexes, especially after age 70, due to long term remodeling inefficiency, dietary inadequacy and activation of the parathyroid axis with age
Unfortunately there are very few physical warning signs for osteoporosis until the disease has established itself. Broken bones or fractures after a minor bump or fall may mean you already have osteoporosis, and this is often the first sign of the disease.
Osteoporosis occurs when the body fails to form enough new bone, when too much of the old bone is reabsorbed by the body, or when there is an imbalance between Osteoclast and Osteoblast activity. The 2 essential minerals for normal bone formation are calcium and phosphate. Throughout youth, the body uses these minerals to produce bones. If calcium intake is not sufficient or if the body does not absorb enough calcium from the diet, bone production and bone tissues may suffer. Calcium and phosphate may be reabsorbed back into the body from the bones, making the bones weaker. Both situations can result in brittle and fragile bones that can break easily.
TYPES OF THERAPY FOR OSTEOPOROSIS
Antiresorptive drugs, already available, slow the progressive thinning of bone.
Bone-building agents help to rebuild the skeleton and are now becoming available or are in the developmental pipeline
Non-pharmacological interventions are also very important in reducing the risk of fracture.
All of the above mentioned treatment strategies need to work hand in hand to prevent Osteoporosis from being such a pain. Pleasant Day
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